A Review: Role of oxidative stress in male infertility

Fanaei, Hamed and Azizi, Yaser and Khayat, Samir (2013) A Review: Role of oxidative stress in male infertility. Journal of Fasa University of Medical Sciences, 3 (2). pp. 93-103.

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Abstract

Recent studies have shown that reactive oxygen species (ROS) have a very important role in the intracellular signaling process in physiological conditions. On the other hand, during the recent decade it has been indicated that ROS play a role in various types of male infertility and it is due to the overproduction of ROS or decrease in the antioxidant defense system in the reproductive system and sperm. In pathological conditions, ROS via interferences in the spermatogenesis process, sperm function, and sperm structure (motility, viability, acrosome reaction, sperm-oocyte fusion, and damage to DNA and cell membrane) as well as reduction in fertilization and implantation can lead to infertility. Knowledge of how ROS affect the physiological process of the reproductive system is crucial in the treatment of infertility. Thus, in this review article we will discuss experimental and clinical findings related to the effects of ROS on male fertility.

Item Type: Article
Uncontrolled Keywords: reactive oxygen species, antioxidant, sperm, male infertility
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 23 Oct 2017 07:18
Last Modified: 23 Oct 2017 07:18
URI: http://eprints.fums.ac.ir/id/eprint/786

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