RIT2 Polymorphisms: Is There a Differential Association?

Emamalizadeh, B. and Jamshidi, J. and Movafagh, A. and Ohadi, M. and Khaniani, M.S. and Kazeminasab, S. and Biglarian, A. and Taghavi, S. and Motallebi, M. and Fazeli, A. and Ahmadifard, A. and Shahidi, G.-A. and Petramfar, P. and Shahmohammadibeni, N. and Dadkhah, T. and Khademi, E. and Tafakhori, A. and Khaligh, A. and Safaralizadeh, T. and Kowsari, A. and Mirabzadeh, A. and Zarneh, A.E.S. and Khorrami, M. and Shokraeian, P. and Banavandi, M.J.S. and Lima, B.S. and Andarva, M. and Alehabib, E. and Atakhorrami, M. and Darvish, H. (2016) RIT2 Polymorphisms: Is There a Differential Association? Molecular Neurobiology. pp. 1-7.

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Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson�s disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders. © 2016 Springer Science+Business Media New York

Item Type: Article
Additional Information: cited By 3; Article in Press
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 10 Mar 2017 17:57
Last Modified: 10 Mar 2017 17:57
URI: http://eprints.fums.ac.ir/id/eprint/77

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