Polycystic Ovary Induction in Mouse by Testosterone Enanthate

Kalhori, Zahra and Azadbakht, Mehri and Bazdar, Ali and Zeinali, Hadis (2014) Polycystic Ovary Induction in Mouse by Testosterone Enanthate. Journal of Fasa University of Medical Sciences, 3 (4). pp. 387-391.

[img] Text
JFUMS-v3n4p387-en.pdf

Download (867kB)
Official URL: http://journal.fums.ac.ir/article-1-137-en.html

Abstract

Background &Objective: Polycystic ovary is the most common cause of infertility in Women. Animal models are required for understanding the pathogenesis of polycystic ovary. The objective of this study then was to develop an animal model for inducing the polycystic ovaries using testosterone enanthate.Materials & Methods: In this study, for inducing the polycystic ovary phenotype, female rats about12-14 days-old were injected daily with testosterone enanthate for 2 and 4 weeks (experiment groups: 1 and 2), while the control groups (1 and 2) were injected only with vehicle.The ovaries from both groups were fixed and then were used for histological studies.Results: Testosterone enanthate treatment causes the histological changes in mouse ovary and significantly increased the percentage of preantral and cystic follicles and decreased the percentage of antral follicles in the experiment group, comparing with the control group (P<0.05).Conclusion: It concluded that testosterone enanthate can induces polycystic ovary in mouse.

Item Type: Article
Uncontrolled Keywords: Testosterone enanthate, Polycystic Ovary, Mouse
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 22 Oct 2017 05:36
Last Modified: 22 Oct 2017 05:36
URI: http://eprints.fums.ac.ir/id/eprint/769

Actions (login required)

View Item View Item