IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis

Yousefi, A. and Mahmoudi, E. and Zare Bidoki, A. and Najmi Varzaneh, F. and Baradaran Noveiry, B. and Sadr, M. and Motamed, F. and Najafi, M. and Farahmand, F. and Rezaei, N. (2016) IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. Expert Review of Gastroenterology and Hepatology, 10 (5). pp. 659-663.

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Abstract

Background: Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants.Method: The studied alleles and genotypes included: IL4G/T allele polymorphisms at position-1098 and C/T allele polymorphisms at two positions (-33 and-590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene.Result: The IL4 C allele and CC genotype at position-590 and TT genotype at position-33 had a significantly higher frequency in AIH patients.Conclusion: This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions. © 2016 Informa UK Limited.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: interleukin 4; interleukin 4 receptor alpha, allele; Article; autoimmune hepatitis; clinical article; controlled study; DNA polymorphism; female; genetic association; genetic susceptibility; genetic variability; genotype; human; interleukin 4 gene; interleukin 4 receptor alpha gene; Iranian (citizen); male; molecular pathology
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 10 Mar 2017 17:53
Last Modified: 10 Mar 2017 17:53
URI: http://eprints.fums.ac.ir/id/eprint/69

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