Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population.

Haghnejad, Leyla and Emamalizadeh, Babak and Jamshidi, Javad and Bidoki, Alireza Zare and Ghaedi, Hamid and Ahmadi, Ehsan and Abdollahi, Shokoufeh and Shahmohammadibeni, Neda and Taghavi, Shaghayegh and Fazeli, Atena and Motallebi, Marzieh and Zarneh, Amir Ehtesham Shafiei and Mohammadihosseinabad, Saeed and Abbaszadegan, Mohammad Reza and Torkamandi, Shahram and Gavenaroudi, Masoumeh Amini and Pedram, Negar and Shahidi, Gholam-Ali and Tafakhori, Abbas and Darvish, Hossein and Movafagh, Abolfazl (2015) Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population. Journal of the neurological sciences, 355 (1-2). pp. 72-4. ISSN 1878-5883

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Abstract

DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3'UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p<0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population.

Item Type: Article
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 09 Mar 2017 18:46
Last Modified: 09 Mar 2017 18:46
URI: http://eprints.fums.ac.ir/id/eprint/441

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