SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population

Zarrabi Alhosseini, M. and Jamshidi, J. and Zare Bidoki, A. and Ganji, S. and Eslami Amirabadi, M.R. and Emamalizadeh, B. and Taghavi, S. and Shokraeian, P. and Mohajerani, F. and Darvish, H. (2016) SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population. Neurological Research, 38 (11). pp. 959-964.

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Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD. Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6�16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6�16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped. Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD. Discussion: To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Divisions: School of Medicine
Depositing User: Unnamed user with email
Date Deposited: 10 Mar 2017 17:41
Last Modified: 10 Mar 2017 17:41

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