Effect of opium smoking on concentrations of carcinoembryonic antigen and tissue polypeptide antigen

Naghibalhossaini, F. and Ay, J. and Alavi, J. and Oveisi, S. and Chahardooli, R. (2004) Effect of opium smoking on concentrations of carcinoembryonic antigen and tissue polypeptide antigen. International Journal of Biological Markers, 19 (4). pp. 305-309.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Previous studies have related opium and its pyrolysates to the risk of developing certain cancers. The aim of this work as to evaluate the clinical usefulness of determining carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) levels in habitual opium smokers. Serum CEA concentrations were measured in 128 opium smokers and in 44 controls of cigarette only smokers and 47 normal non-smokers by an EIA-based assay. TPA levels were also determined in serum and urine of a subgroup in the study population. The results indicated that serum CEA concentrations are higher in opium smokers than in healthy tobacco smokers (p=0.004) and non-smokers (p=0.001). The amount of opium used correlated with the serum CEA level (r=0.276, p<0.0001). The mean urine and serum TPA levels of the opium-addicted population were also higher than that of the non-smoking control group, but the differences were not statistically significant. We conclude that opium smoking is associated with elevated serum CEA levels. Therefore, for management of opium users with neoplastic diseases, increased levels of serum CEA should be viewed with caution to avoid misdiagnosis. © 2004 Wichtig Editore.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: carcinoembryonic antigen; opiate; tissue polypeptide antigen, adult; aged; article; blood level; cigarette smoking; controlled study; correlation analysis; diagnostic error; drug abuse; electroimmunoassay; female; human; major clinical study; male; neoplasm; opiate addiction; patient care; smoking habit; statistical significance; urine level, Adult; Aged; Carcinoembryonic Antigen; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasms; Opium; Smoking; Substance-Related Disorders; Tissue Polypeptide Antigen; Tumor Markers, Biological, Nicotiana tabacum
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 09 Mar 2017 20:46
Last Modified: 09 Mar 2017 20:46
URI: http://eprints.fums.ac.ir/id/eprint/324

Actions (login required)

View Item View Item