Serum insulin in pathogenesis and treatment of osteoarthritis.

Askari, Alireza and Ehrampoush, Elham and Homayounfar, Reza and Bahramali, Ehsan and Farjam, Mojtaba (2017) Serum insulin in pathogenesis and treatment of osteoarthritis. Medical hypotheses, 99. pp. 45-46. ISSN 1532-2777

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Abstract

Osteoarthritis (OA) is one of the major health problems that's development and progression is obesity-related. We believe that higher levels of insulin may explains this link especially. High levels of insulin in obesity and metabolic syndrome can induce numerous complications. Insulin can increase proliferation of chondrocyte but simultaneously, it prevents their differentiation. Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes. So maybe decreasing insulin levels, prevents OA progression or improve the treatment process.

Item Type: Article
Subjects: QS Human Anatomy
QT Physiology
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 08 Mar 2017 20:50
Last Modified: 08 Mar 2017 20:50
URI: http://eprints.fums.ac.ir/id/eprint/3

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