Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

Salehi, M. and Shahporzadeh, K. and Ehterami, A. and Yeganehfard, H. and Ziaei, H. and Azizi, M.M. and Farzamfar, S. and Tahersoltani, A. and Goodarzi, A. and Ai, J. and Ahmadi, A. (2020) Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study. Fibers and Polymers.

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Abstract

In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in order to fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1 (w/w)) solution supplemented with 1 and 10 (w/v) of selenium particles. Prepared wound dressings were investigated regarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 and 10 selenium and selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after 14 days, the wound closure of the mat containing 1 selenium was about 95.5±6.38 while wound closure of the negative control group was about 48.83±4.03 . Our results showed the capability of nanofibrous containing selenium for successful wound treatment. © 2020, The Korean Fiber Society.

Item Type: Article
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 07 Nov 2020 07:43
Last Modified: 07 Nov 2020 07:43
URI: http://eprints.fums.ac.ir/id/eprint/2774

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