In vitro evaluation of Zeolite-nHA blended PCL/PLA nanofibers for dental tissue engineering

Mohandesnezhad, S. and Pilehvar-Soltanahmadi, Y. and Alizadeh, E. and Goodarzi, A. and Davaran, S. and Khatamian, M. and Zarghami, N. and Samiei, M. and Aghazadeh, M. and Akbarzadeh, A. (2020) In vitro evaluation of Zeolite-nHA blended PCL/PLA nanofibers for dental tissue engineering. Materials Chemistry and Physics.

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Abstract

This study aimed to investigate the potential of a composite poly(lactic acid)/polycaprolactone (PLA/PCL) blend electrospun nanofiber containing both nano-hydroxyapatite (nHA) and zeolite for promoting the proliferation of human dental pulp-derived stem cells (hDPSCs) with possible application in dental tissue engineering. For this purpose, nHA and Zeolite were synthesized via the hydrothermal method and their morphological features and crystals properties were studied by FE-SEM and X-ray diffraction, respectively. PCL-PLA/nHA/zeolite nanofibers were fabricated via electrospinning and characterized through FT-IR and water contact angle measurement methods. Then, the viability and adhesion of hDPSCs on the fibers were investigated by MTT assay and FE-SEM, respectively. The results showed that the viability of hDPSCs on the PCL-PLA/Zeolite scaffolds was significantly improved after 1, 7 and 14 days of culturing and maximum enhancing on the cell viability was detected after 3 days on PCL-PLA/nHA scaffolds (P � 0.001). After 7 and 14 days of incubation, cell growth on the scaffolds containing both nHA and Zeolite was better than the nanofibers which were loaded with nHA alone. Briefly, these results revealed that Zeolite-loaded nanofiber is the most suitable scaffold for bone and tooth tissue engineering applications. More studies are required to investigate the efficiency of zeolite-based nanofibrous scaffolds for the development of artificial scaffolds for dental tissue regeneration. © 2020 Elsevier B.V.

Item Type: Article
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 07 Nov 2020 08:11
Last Modified: 07 Nov 2020 08:11
URI: http://eprints.fums.ac.ir/id/eprint/2759

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