Histometric and histopathologic study of soybean hydroalcoholic extract on testicular tissue and pituitary- gonad axis in adult male rat

Ahsannia, N. and Zahiri, S. and Mahjour, A.A. and Tavasoli, A. and Safarpour, D. (2011) Histometric and histopathologic study of soybean hydroalcoholic extract on testicular tissue and pituitary- gonad axis in adult male rat. Journal of Mazandaran University of Medical Sciences, 21 (85). pp. 91-98.

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Abstract

Background and purpose: Studies have indicated that phytoestrogens in soybean can influence the reproductive system. The aim of this study was to investigate the effect of hydroalcoholic extract of soybean on testicular tissue and pituitary-gonad axis in male rat. Materials and methods: Forty adult male Wistar rats were randomly allocated into five groups including control, sham, and three experimental. Animals in the experimental groups received soybean extract for 48 days at doses of 30, 60, and 120 mg/kg by gavage, respectively. The rats in the sham group received only water by gavage for the same period, as well. In the control group received no treatment. Animals' weight was measured before and after the intervention. After that, the animals were anesthetized and the levels of LH, FSH, and testosterone hormones were measured by collecting blood from their hearts. In the end, the left and right testes were removed and weighed. Quantitative and qualitative studies were done on the left testis of each rat. Results: Administration of soybean hydroalcoholic extract at doses of 30, 60, and 120 mg/kg did not have any negative effect on body weight, gonads, testicular function, and histometric parameters. Administration of extract with the highest dose used in this study (120 mg/kg) significantly decreased the plasma LH level, germinal epithelium length, and repopulation index (P<0.05). Furthermore, histopathologic studies did not show any damage on testicular tissue. Conclusion: The results indicated that soybean in routine doses that used in this study did not exert considerable negative effects on testicular tissue and hormone secretion in the rats.

Item Type: Article
Additional Information: cited By 0
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 09 Mar 2017 21:31
Last Modified: 09 Mar 2017 21:31
URI: http://eprints.fums.ac.ir/id/eprint/268

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