The role of magnesium in different inflammatory diseases

Shahi, Abbas and Aslani, Saeed and Ataollahi, MohammadReza and Mahmoudi, Mahdi The role of magnesium in different inflammatory diseases. INFLAMMOPHARMACOLOGY, 27 (4). pp. 649-661.

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Abstract

Magnesium deficiency (MgD) can cause inflammation in human body. The known mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening of calcium channels, activation of the N-methyl-d-aspartate (NMDA) receptor, and activation of nuclear factor (NF)-kappa B. In addition, MgD causes systemic stress response through neuroendocrinological pathways. The inflammation caused by MgD can result in pro-atherogenic changes in the metabolism of lipoproteins, endothelial dysfunction, and high blood pressure. Studies suggest that magnesium may play an important role in the pathophysiology of some inflammatory diseases. Several clinical trials and laboratory studies have been done on the functional role of magnesium. In this study, we review some inflammatory diseases, in which the magnesium has a role in their pathophysiology. Among these diseases, diabetes, asthma, preeclampsia, atherosclerosis, heart damage, and rheumatoid arthritis have been highlighted.

Item Type: Article
Uncontrolled Keywords: Magnesium; Magnesium deficiency; Inflammation; Asthma; Autoimmunity
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 19 Jul 2020 04:48
Last Modified: 19 Jul 2020 04:48
URI: http://eprints.fums.ac.ir/id/eprint/2582

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