Interleukin-6 and E-selectin in acute coronary syndromes and stable angina pectoris: A comparative study

Sarrafzadegan, N. and Sadeghi, M. and Ghaffarpasand, F. and Alisaeidi, A. and Sanei, H. and Zakeri, H. and Rastegar, T. and Amiri, A. and Dehghankhalili, M. (2012) Interleukin-6 and E-selectin in acute coronary syndromes and stable angina pectoris: A comparative study. Herz, 37 (8). pp. 926-930.

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Abstract

Objectives: The purpose of the study was to compare the serum levels of interleukin-6 (IL-6), E-selectin, and trans-fatty acids (TFA) between those with stable and unstable angina pectoris. Methods: From September 2008 to March 2009, a case-control study was performed at two university hospitals. We included 89 patients with acute coronary syndrome (ACS) including patients with myocardial infarction and those with unstable angina pectoris (case group) and 93 patients with stable angina pectoris (control group). The two groups were matched with respect to demographic characteristics and risk factors of cardiovascular diseases. Serum levels of IL-6 and E-selectin were measured using the enzyme linked immunosorbent assay, while TFA and lipoproteins were measured using gas chromatography and enzymatic methods, respectively. Results: No significant differences between baseline characteristics of the two study groups were observed. Patients with stable angina had significantly higher serum levels of total cholesterol (187.0 ± 3.7 vs. 171.6 ± 4.2 mg/dl; p = 0.009), low density lipoproteins (104.8 ± 2.4 vs. 95.4 ± 2.7; p = 0.017), and TFA (1.41 ± 0.47 vs. 1.24 ± 0.69 mg/dl; p = 0.047) compared to those with ACS. Serum levels of IL-6 were found to be significantly higher in those with stable angina compared to those with ACS (102.4 ± 1.9 vs. 224.6 ± 3.6; p = 0.007). However, patients with ACS had higher levels of E-selectin (53.5 ± 25.7 vs. 49.2 ± 23.5 μg/dl; p = 0.52), but the difference did not reach statistical significance. Conclusion: In the current study, inflammation as measured by IL-6 and E-selectin was not found to play an important role in progression of ischemic heart disease from stable angina to unstable angina or myocardial infarction, which is contrary to previous studies. © 2012 Urban & Vogel, Muenchen.

Item Type: Article
Additional Information: cited By 11
Uncontrolled Keywords: cholesterol; endothelial leukocyte adhesion molecule 1; interleukin 6; lipoprotein; low density lipoprotein; trans fatty acid; biological marker; endothelial leukocyte adhesion molecule 1; IL6 protein, human; interleukin 6; SELE protein, human, acute coronary syndrome; adult; article; blood level; cardiovascular risk; case control study; comparative study; controlled study; demography; disease course; enzyme analysis; enzyme linked immunosorbent assay; female; gas chromatography; human; major clinical study; male; non ST segment elevation myocardial infarction; risk factor; ST segment elevation myocardial infarction; stable angina pectoris; university hospital; unstable angina pectoris; acute coronary syndrome; blood; incidence; Iran; middle aged; multicenter study; reproducibility; sensitivity and specificity; stable angina pectoris, Acute Coronary Syndrome; Angina, Stable; Biological Markers; E-Selectin; Female; Humans; Incidence; Interleukin-6; Iran; Male; Middle Aged; Reproducibility of Results; Risk Factors; Sensitivity and Specificity
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 09 Mar 2017 22:09
Last Modified: 09 Mar 2017 22:09
URI: http://eprints.fums.ac.ir/id/eprint/226

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