HLA-DRA is associated with Parkinson's disease in Iranian population

Jamshidi, J. and Movafagh, A. and Emamalizadeh, B. and Zare Bidoki, A. and Manafi, A. and Ghasemi Firouzabadi, S. and Shahidi, G.-A. and Kazeminasab, S. and Petramfar, P. and Fazeli, A. and Motallebi, M. and Mortazavi-Tabatabaei, S.A. and Kowsari, A. and Jafarian, Z. and Darvish, H. (2014) HLA-DRA is associated with Parkinson's disease in Iranian population. International Journal of Immunogenetics, 41 (6). pp. 508-511.

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The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls (�2 = 4.64, P = 0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data. © 2014 John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: HLA DR antigen, allele; biological model; case control study; female; gene frequency; genetic association; genetic predisposition; genetics; human; inheritance; Iran; male; middle aged; Parkinson disease; single nucleotide polymorphism, Alleles; Case-Control Studies; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; HLA-DR alpha-Chains; Humans; Inheritance Patterns; Iran; Male; Middle Aged; Models, Genetic; Parkinson Disease; Polymorphism, Single Nucleotide
Subjects: WL Nervous system
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 10 Mar 2017 17:34
Last Modified: 11 Mar 2017 16:25
URI: http://eprints.fums.ac.ir/id/eprint/190

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