Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group

Dastgheib, L. and Mostafavi-Pour, Z. and Abdorazagh, A.A. and Khoshdel, Z. and Sadati, M.S. and Ahrari, I. and Ahrari, S. and Ghavipisheh, M. (2014) Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group. Dermatology Research and Practice, 2014.

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Abstract

Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. Materials and Methods. Sixteen female patients with AA (14-40 years old) and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15. Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron (r = 0.504, P = 0.001), zinc (r = 0.684, P = 0.0001), and copper (r = 0.759, P = 0.0001) in patients and controls. Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients. © 2014 Ladan Dastgheib et al.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cuprous ion; iron; zinc ion, adolescent; adult; alopecia areata; Article; atomic absorption spectrometry; autoimmune disease; case control study; clinical article; comparative study; controlled study; copper blood level; female; flame photometry; hair level; human; investigative procedures; iron blood level; zinc blood level
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 10 Mar 2017 17:35
Last Modified: 10 Mar 2017 17:35
URI: http://eprints.fums.ac.ir/id/eprint/188

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