Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population

Haghnejad, L. and Emamalizadeh, B. and Jamshidi, J. and Bidoki, A.Z. and Ghaedi, H. and Ahmadi, E. and Abdollahi, S. and Shahmohammadibeni, N. and Taghavi, S. and Fazeli, A. and Motallebi, M. and Zarneh, A.E.S. and Mohammadihosseinabad, S. and Abbaszadegan, M.R. and Torkamandi, S. and Gavenaroudi, M.A. and Pedram, N. and Shahidi, G.-A. and Tafakhori, A. and Darvish, H. and Movafagh, A. (2015) Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population. Journal of the Neurological Sciences, 355 (1-2). pp. 72-74.

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Abstract

DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3�UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p < 0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population. © 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: microRNA; microRNA 433; unclassified drug; FGF20 protein, human; fibroblast growth factor, 3' untranslated region; adult; Article; binding site; controlled study; female; gene frequency; genetic association; genetic risk; genetic variability; genotype; human; Iran; major clinical study; male; middle aged; Parkinson disease; priority journal; restriction fragment length polymorphism; aged; chi square distribution; genetic predisposition; genetics; Parkinson disease; risk factor; single nucleotide polymorphism, Aged; Chi-Square Distribution; Female; Fibroblast Growth Factors; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Iran; Male; Middle Aged; Parkinson Disease; Polymorphism, Single Nucleotide; Risk Factors
Divisions: School of Medicine
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 10 Mar 2017 17:26
Last Modified: 10 Mar 2017 17:26
URI: http://eprints.fums.ac.ir/id/eprint/167

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