RIT2 Polymorphisms: Is There a Differential Association?

Emamalizadeh, Babak and Jamshidi, Javad and Movafagh, Abolfazl and Ohadi, Mina and Khaniani, Mahmoud Shekari and Kazeminasab, Somayyeh and Biglarian, Akbar and Taghavi, Shaghayegh and Motallebi, Marzieh and Fazeli, Atena and Ahmadifard, Azadeh and Shahidi, Gholam-Ali and Petramfar, Peyman and Shahmohammadibeni, Neda and Dadkhah, Tahereh and Khademi, Ehteram and Tafakhori, Abbas and Khaligh, Ali and Safaralizadeh, Tannaz and Kowsari, Ali and Mirabzadeh, Arash and Zarneh, Amir Ehtesham Shafiei and Khorrami, Mehdi and Shokraeian, Parasto and Banavandi, Mohammad Javad Soltani and Lima, Behnam Safarpour and Andarva, Monavvar and Alehabib, Elham and Atakhorrami, Minoo and Darvish, Hossein RIT2 Polymorphisms: Is There a Differential Association? MOLECULAR NEUROBIOLOGY, 54 (3). pp. 2234-2240.

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Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.

Item Type: Article
Depositing User: Unnamed user with email eprints@fums.ac.ir
Date Deposited: 31 Oct 2017 07:05
Last Modified: 31 Oct 2017 07:05
URI: http://eprints.fums.ac.ir/id/eprint/1451

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